Hypoxia induces the overexpression of microRNA-21 in pancreatic cancer cells
نویسندگان
چکیده
منابع مشابه
MicroRNA‐21 induces 5‐fluorouracil resistance in human pancreatic cancer cells by regulating PTEN and PDCD4
Pancreatic cancer patients are often resistant to chemotherapy treatment, which results in poor prognosis. The objective of this study was to delineate the mechanism by which miR-21 induces drug resistance to 5-fluorouracil (5-FU) in human pancreatic cancer cells (PATU8988 and PANC-1). We report that PATU8988 cells resistant to 5-FU express high levels of miR-21 in comparison to sensitive prima...
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Due to the poor prognosis of pancreatic cancer, novel diagnostic modalities for early diagnosis and new therapeutic strategy are urgently needed. Recently, microRNA-21 (miR-21) was reported to be strongly overexpressed in pancreatic cancer as well as in other solid cancers. We investigated the functional roles of miR-21, which have not been fully elucidated in pancreatic cancer. miR-21 expressi...
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ژورنال
عنوان ژورنال: Journal of Surgical Research
سال: 2013
ISSN: 0022-4804
DOI: 10.1016/j.jss.2013.04.061